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目的探讨肝动脉栓塞化疗术(TACE)治疗原发性肝癌不同栓塞剂对血常规三系的影响。方法 60例原发性肝癌患者,依据接受栓塞剂的不同分为海藻酸钠组和碘化油组,每组30例。海藻酸钠组接受海藻酸钠-TACE治疗,碘化油组接受碘化油-TACE治疗。术前1周及术后第5天抽血检查,评价血常规三系的情况。结果 1海藻酸钠组:TACE后第5天血液红细胞(3.8±0.8)×10~(12)/L和血小板(121±62)×10~9/L较TACE前(4.3±0.8)×10~(12)/L、(166±86)×10~9/L下降,差异具有统计学意义(P<0.05);TACE前与TACE后第5天血液白细胞比较差异无统计学意义(P>0.05)。2碘化油组:TACE后第5天血液红细胞(3.8±0.8)×10~(12)/L和血小板(120±68)×10~9/L较TACE前(4.3±0.9)×10~(12)/L、(167±87)×10~9/L下降,差异具有统计学意义(P<0.05);TACE前与TACE后第5天血液白细胞比较差异无统计学意义(P>0.05)。3两组患者TACE后第5天血常规三系比较,差异均无统计学意义(P>0.05)。结论海藻酸钠和碘化油作为TACE的栓塞剂,均会导致一定程度的血液红细胞和血小板降低,但是两者的影响无差异,总体较为安全。
Objective To investigate the effect of transcatheter arterial chemoembolization (TACE) on blood routine three-line system in patients with primary liver cancer. Methods Sixty patients with primary liver cancer were divided into sodium alginate group and iodized oil group according to the different embolic agents, with 30 cases in each group. Sodium alginate group received sodium alginate-TACE treatment, iodized oil group received iodized oil-TACE treatment. 1 week before surgery and 5 days after surgery, blood tests to assess the situation of blood three lines. Results 1 Sodium alginate group: Compared with the pre-TACE (4.3 ± 0.8) × 10 (3), the erythrocytes (3.8 ± 0.8) × 10-12 / L and the platelets (121 ± 62) × 10-9 / (P <0.05). There was no significant difference in blood leukocytes between before TACE and the fifth day after TACE (P> 0.05). In iodized oil group, the levels of erythrocyte (3.8 ± 0.8) × 10-12 / L and platelets (120 ± 68) × 10-9 / L on the 5th day after TACE were significantly higher than those before TACE (4.3 ± 0.9) (P <0.05). There was no significant difference in blood leukocytes between pre-TACE and 5th day after TACE (P> 0.05) ). There was no significant difference between the three groups in the blood routine on day 5 after TACE (P> 0.05). Conclusions Both sodium alginate and iodized oil, as the embolization agents of TACE, will lead to a certain degree of decrease of erythrocytes and platelets in blood, but the difference between the two is not significant and the overall safety is relatively safe.