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目的:探讨Bcl-2和Ki-67在眼附属器MALT淋巴瘤中的表达情况及其对患者预后的影响。方法:收集2001-12/2005-02在我院收治的眼附属器MALT淋巴瘤17例,采用免疫组织化学的方法检测Bcl-2和Ki-67蛋白的表达情况。对患者进行随访,分析Bcl-2和Ki-67蛋白的表达情况与临床病理特征及生存状况的关系。结果:17例眼附属器MALT淋巴瘤中有12例(70.6%)表达Bcl-2蛋白阳性,有10例(58.8%)呈Ki-67蛋白高表达。Bcl-2蛋白表达与Ann Arbor分期明显相关(P<0.05),Ki-67蛋白表达与年龄、Ann Arbor分期明显相关(P<0.05)。Bcl-2阳性组、阴性组平均生存期分别为29.8月和62.4月,Ki-67高表达组、低表达组平均生存期分别为27.2月和58.9月。生存分析显示Bcl-2阴性组、Ki-67低表达组生存期较长,Kaplan Merier生存曲线明显不同(P<0.05)。结论:Bcl-2和Ki-67是评价眼附属器MALT淋巴瘤生物学行为的参考指标,并对肿瘤的预后有较好的指导意义。
Objective: To investigate the expression of Bcl-2 and Ki-67 in ocular adnexal MALT lymphoma and its effect on the prognosis of patients. Methods: 17 cases of ocular adnexal MALT lymphoma treated in our hospital from December 2001 to February 2005 were enrolled in this study. The expressions of Bcl-2 and Ki-67 were detected by immunohistochemistry. The patients were followed up and analyzed the relationship between the expression of Bcl-2 and Ki-67 protein and clinicopathological characteristics and survival status. Results: Bcl-2 protein was positive in 12 cases (70.6%) of 17 cases with ocular adnexal MALT lymphoma. Ki-67 protein was highly expressed in 10 cases (58.8%). The expression of Bcl-2 protein was significantly correlated with Ann Arbor stage (P <0.05). Ki-67 protein expression was significantly correlated with age and Ann Arbor stage (P <0.05). The average survival time of Bcl-2 positive group and negative group were 29.8 months and 62.4 months, respectively. Ki-67 overexpression group and low expression group mean survival time was 27.2 months and 58.9 months respectively. Survival analysis showed that the survival of Bcl-2 negative group and Ki-67 low expression group were longer than that of Kaplan Merier (P <0.05). Conclusions: Bcl-2 and Ki-67 are the reference indices for evaluating the biological behavior of ocular adnexal MALT lymphoma, and have a good guiding significance for the prognosis of the tumor.