论文部分内容阅读
DNA羟甲基化修饰主要是指5-甲基胞嘧啶(5-methylcytosine,5m C)在10-11易位(ten-eleven translocation,TET)蛋白家族的氧化作用下生成5-羟甲基胞嘧啶(5-hydroxymethylcytosine,5hm C)。5hm C不仅能在去甲基化过程中起重要作用,而且还参与了基因的表达调控。5hm C的含量有着高度的组织特异性,且目前在中枢神经系统中也发现了高水平的5hm C。与神经系统疾病相关的基因中存在明显的5hm C水平的改变,暗示着DNA羟甲基化修饰很可能在神经系统疾病的发生与发展过程中起了重要作用。
DNA methylation modification mainly refers to the 5-methylcytosine (5mC) generating 5-hydroxymethyl cell under the oxidation of 10-11 translocation (TET) protein family Pyrimidine (5-hydroxymethylcytosine, 5hm C). 5hm C not only plays an important role in demethylation, but also participates in the regulation of gene expression. The content of 5hm C is highly tissue-specific and so far a high level of 5hm C has also been found in the central nervous system. There is a significant 5hm C level change in genes related to nervous system diseases, suggesting that DNA methylation modification may play an important role in the occurrence and development of nervous system diseases.