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应用间接免疫荧光法检测22例病毒肺炎患儿和30例健康儿童外周血 T 细胞亚群,结果表明病毒肺炎患儿的 CD_3,CD_4阳性细胞率明显低于健康儿童;其 CD_3阳性细胞率和 CD_4/CD_3与健康儿童无显著差异.22倒病毒肺炎患儿中有7例患儿的 CD_4/CD_3低于正常范围.说明病毒感染可引起细胞免疫病变,同时也为临床诊断病毒肺炎提供了辅助依据.用α—干挠素(α—IFN)治疗患者,6例于疗后恢复期复查 T 细胞亚群,有5例基本恢复正常.提示 IFN可能对病毒性肺炎治疗有效.另外,危重病毒肺炎患儿的 T 细胞亚群变化与临床表现有一定相关性。
The results of indirect immunofluorescence assay showed that the percentage of CD_3 and CD_4 positive cells in children with viral pneumonia was significantly lower than that in healthy children. The positive rates of CD_3 and CD_4 / CD_3 had no significant difference with healthy children.22 CD_4 / CD_3 of 7 children with RV pneumonia were lower than the normal range, indicating that viral infection could cause cellular immune lesions and also provide a supplementary evidence for the clinical diagnosis of viral pneumonia .In the treatment of patients with α-interferon (IFN-α), 6 cases of T cell subsets in the recovery period after treatment, 5 cases returned to normal, suggesting that IFN may be effective in the treatment of viral pneumonia.In addition, severe viral pneumonia T cell subsets in children with changes in clinical manifestations have some relevance.