论文部分内容阅读
[目的]评价并比较CA50和CA242在胰腺癌诊断中的应用价值。[方法]测定101例胰腺癌、60例胰腺良性疾病和55例健康体检者血清CA50及CA242水平,以诊断效能参数及ROC曲线评价二者对胰腺癌的诊断价值,并评估二者联合诊断效能。[结果]胰腺癌组CA50及CA242水平明显高于良性疾病组和健康对照组(P<0.001)。CA50和CA242诊断胰腺癌的ROC曲线下面积分别为0.893(95%CI:0.833~0.918)和0.834(95%CI:0.795~0.971);二者对胰腺癌诊断界值(cutoff值)分别为18.68U/ml和16.45U/ml,敏感性为91.1%和78.2%,特异性为70.4%和78.3%。CA50与CA242以cutoff值为基础联合检测的敏感性为95.0%,特异性为69.6%,Youden指数为0.65,阳性预测值为73.3%,阴性预测值为94.1%。[结论]CA50对胰腺癌的诊断价值高于CA242,二者联合检测可提高诊断效能。
[Objective] To evaluate and compare the value of CA50 and CA242 in the diagnosis of pancreatic cancer. [Method] The serum levels of CA50 and CA242 in 101 cases of pancreatic cancer, 60 cases of benign pancreatic diseases and 55 cases of healthy subjects were measured. The diagnostic value and ROC curve were used to evaluate the diagnostic value of the two methods in pancreatic cancer. The diagnostic efficacy . [Results] The levels of CA50 and CA242 in pancreatic cancer group were significantly higher than those in benign disease group and healthy control group (P <0.001). The area under the ROC curve of CA50 and CA242 for diagnosis of pancreatic cancer were 0.893 (95% CI: 0.833-0.918) and 0.834 (95% CI 0.795-0.971) respectively. The cutoff values of the two for pancreatic cancer were 18.68 U / ml and 16.45U / ml, the sensitivity was 91.1% and 78.2%, the specificity was 70.4% and 78.3%. The combined detection of CA50 and CA242 based on the cutoff value showed a sensitivity of 95.0%, a specificity of 69.6%, a Youden index of 0.65, a positive predictive value of 73.3% and a negative predictive value of 94.1%. [Conclusion] The diagnostic value of CA50 for pancreatic cancer is higher than that of CA242, and the combination of both can improve the diagnostic efficacy.