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心钠素(atrial natriuretic factor,ANF)是由人和哺乳类动物心房肌细胞分泌的、新发现的一类循环激素,具有强大的利钠、利尿、扩张血管和抑制肾素—血管紧张素—醛固酮系统RAAS的作用(Renin—Angiotensin—Aidosterone System).肺动脉高压PHT(Pulmonary Hypertension),对血浆 ANF浓度PANFC(Plasma Concentration of Atrial NatriureticFactor)明显升高及用外源性ANF治疗PHT取得了初步成功,由此推测ANF参与了PHT的病理生理过程.本文重点叙述ANF在PHT时的变化和意义及用外源性ANF治疗PHT.
Atrial natriuretic factor (ANF), a newly discovered class of circulating hormone secreted by human and mammalian atrial myocytes, has potent sodium, diuretic, dilated blood vessels and inhibits renin-angiotensin- Renin-Angiotensin-Aidosterone System. Pulmonary Hypertension (PHT) has achieved initial success when plasma concentration of Atrial Natriuretic Factor (PANFC) is significantly increased and exogenous ANF is used to treat PHT. It is speculated that ANF is involved in the pathophysiology of PHT.This article focuses on the changes and significance of ANF in PHT and the treatment of PHT with exogenous ANF.