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人绒毛膜促性腺激素(HCG)是一种糖蛋白,由α及β亚单位非共价结合而成。正常情况下,HCG 系由妊娠滋养细胞分泌,在孕妇及滋养细胞肿瘤病人血、尿中可测出,并可测出游离形式的 HCGα或β亚单位,其量占分泌的 HCG0.5～30%。β-核心片断是失去羧基终末端的 HCG-β亚单位,包括β-肽链中第6～40个氨基酸及第55～92个氨基酸,两段氨基酸序列出二硫键相结合。该片断只能由尿中检出。孕妇及滋养细胞肿瘤病人尿β-核心片断水平往往高于HCG。近来对(?)个非滋养细胞性肿瘤细胞株的研究发现全部分泌某种形式的 HCG 亚单位,
Human chorionic gonadotropin (HCG) is a glycoprotein that is formed by the non-covalent association of alpha and beta subunits. Under normal circumstances, HCG is secreted by gestational trophoblast cells, measurable in the blood and urine of pregnant women and trophoblastic tumor patients, and can be measured free form of HCGα or β subunit, the amount of HCG secretion accounted for 0.5 to 30 %. The β-core fragment is the HCG-β subunit that has lost its carboxyl terminal, including the 6th to 40th amino acids and the 55th to 92th amino acids in the β-peptide chain, and the two amino acid sequences are disulfide bonded. The piece can only be detected in the urine. Pregnancy and trophoblastic tumor patients urinary beta-core fragment levels are often higher than HCG. Recent studies of (?) Non-trophoblastic tumor cell lines have all revealed the secretion of some form of HCG subunit,