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克山病(Keshan Disease、简称 KSD)与纤维囊性病(Cystic Fibrosis 简称 CF)有其共同特点,如心肌呈散在性灶性坏死和纤维变,发病年龄多为胎儿或学龄前儿童等。而肝脏和胰腺损害为纤维囊性病的特征性病变。本文作者对克山病尸检材料作了进一步研究。在已确诊的1700例克山病病例中发现595例(35%)有纤维囊性病的胰腺改变,均为胎儿和学龄前儿童。其中850例(50%)表现出不同程度的灶性胆汁性肝硬变,85例(5%)发展成严重的小叶性肝硬化。纤维囊性病和克山病的另一共同点是易感个体的硒元素缺乏,易感个体多为胎龄17周至6个月的胎儿或是早期幼儿。克山病和纤维囊性病缺硒的表现是有区别的,但在基本的细胞水平及组织水平的病理生理学上,二者即便不是完全一致,已是十分相近的。
Keshan Disease (KSD) and Cystic Fibrosis (CF) have their common features, such as diffuse focal myocardial necrosis and fibrosis, the onset of age and more for the fetus or preschool children. Liver and pancreas damage is a characteristic cystic fibrosis disease. The author of the Keshan autopsy material for further study. Of the 1700 cases of Keshan disease that have been diagnosed, 595 (35%) have pancreatic changes of fibrocystic disease, both fetuses and pre-school children. Of these, 850 (50%) showed varying degrees of focal biliary cirrhosis and 85 (5%) developed severe lobular cirrhosis. Another common denominator of fibrocystic disease and Keshan disease is the lack of selenium in susceptible individuals, mostly fetuses 17 to 6 months of age or early stage infants. Keshan disease and fibrocystic disease selenium performance is different, but at the basic cellular and tissue level of the pathophysiology, the two are not exactly the same, are already very similar.