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由维生素B_1不足所致的蛋白质代谢障碍,至今尚无合理解释.据推测,这与蛋白质合成障碍有关.作者为证实此假说,用一次大剂量(400mg/Kg)注入抗维生素B_1,代谢药物-羟硫胺,以引起大白鼠急性维生素B_1不足的办法,来进行肝线粒体蛋白质合成的研究.实验结果发现,注入羟硫胺24或72小时后,大白鼠肝线粒体蛋白质中的标记氯基酸比对照组动物和注入同剂量硫胺素的动物要高.
To date, there is no reasonable explanation for the protein metabolism disorder caused by the deficiency of vitamin B 1. It is speculated that this is related to protein synthesis disorder.In order to confirm this hypothesis, we injected a large dose (400mg / Kg) of anti-vitamin B 1, Hydroxythiamine to induce acute deficiency of vitamin B 1 in rats was used to study the synthesis of hepatic mitochondrial protein.Experimental results showed that after 24 or 72 hours of injection of hydroxythiamine, the ratio of labeled chloride to acid in rat liver mitochondrial protein Control animals and animals injected with the same dose of thiamine were higher.