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目的探讨不同剂量的米索前列醇对减少产后出血量的影响。方法将240例第1、2产程正常的初产妇随机分为A、B、C3组,每组各80例,分别于胎肩娩出后肌内注射催产素20U,B组加用米索前列醇0.2mg舌下含化,C组加米索前列醇0.2mg舌下含化及0.2mg塞肛。比较各组产后出血量及产后出血发生情况。结果A、B、C组产后24h出血量≥500ml的发生率分别为22.5%、15.0%、10.0%,A组明显高于C组(22.5%vs10.0%,P<0.05),A与B组及B与C组分别两两比较,差异均无统计学意义(P均>0.05)。结论米索前列醇对减少产后出血量及预防产后出血安全、有效、经济、毒副作用小。
Objective To investigate the effects of different doses of misoprostol on postpartum hemorrhage. Methods A total of 240 primiparous women with first and second stage of labor were randomly divided into A, B, and C3 groups, 80 cases in each group. The nude mice were intramuscularly injected with 20 U of oxytocin after the delivery of the shoulder. B group was treated with misoprostol 0.2mg sublingual, C plus misoprostol 0.2mg sublingual and 0.2mg plug anal. Compare the amount of postpartum hemorrhage and postpartum hemorrhage in each group. Results The incidences of hemorrhage≥500ml in group A, B and C after birth were 22.5%, 15.0% and 10.0%, respectively, and those in group A were significantly higher than those in group C (22.5% vs 10.0%, P <0.05) There was no significant difference between groups B and C (P> 0.05). Conclusion Misoprostol is safe, effective, economical and has little toxic and side effects on reducing postpartum hemorrhage and preventing postpartum hemorrhage.