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目的：研究粉防己碱（Ｔｅｔ）和阿霉素（Ｄｏｘ）或长春新碱（Ｖｉｎ）联合用药在体外分别对人乳腺癌细胞ＭＣＦ７及其抗Ｄｏｘ细胞ＭＣＦ７／Ｄｏｘ或人口腔上皮样癌细胞ＫＢ及其抗Ｖｉｎ细胞ＫＢＶ２００的相互作用的性质．方法：ＭＴＴ法测定Ｔｅｔ和Ｄｏｘ或Ｖｉｎ单独用药或联合用药的抗癌活性．抑制浓度的分数之和（ＳＦＩＣ）值及等效剂量分析方法（Ｉｓｏｂｏｌｏｇｒａｍ）评价Ｔｅｔ和Ｄｏｘ或Ｖｉｎ联合用药的相互作用的性质．结果：Ｔｅｔ和Ｄｏｘ或Ｖｉｎ联合用药时分别以三种不同比例配伍，其ＳＦＩＣ值均小于１．由此联合用药得到的等效剂量曲线图形均为凹形．结论：Ｔｅｔ和Ｄｏｘ或Ｖｉｎ体外联合用药抗癌相互作用的性质为明显的增效作用
OBJECTIVE: To study the effects of combination of tetrandrine (Tet) and doxorubicin (Dox) or vincristine (Vin) on human breast cancer cells MCF7 and their anti-Dox cells MCF7 / Dox or human oral epithelial The nature of the interaction between the so-called cancer cell KB and its anti-Vin cell KBV200. Methods: The antitumor activity of Tet and Dox or Vin alone or in combination was determined by MTT assay. The fractional inhibition of concentration (SFIC) value and the equivalent dose analysis method (Isobologram) were used to evaluate the nature of the interaction of Tet with Dox or Vin. Results: The combination of Tet and Dox or Vin with three different proportions respectively, the SFIC values were less than 1. The equivalent dose curve obtained by the combination therapy is concave. CONCLUSIONS: The anticancer interaction between Tet and Dox or Vin in vitro is a synergistic effect