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1981年～1983年对某化工厂氯乙烯车间的生产条件进行了改善,使车间空气中氯乙烯浓度基本达到国家最高容许浓度(30mg/m~3),对改善前后的氯乙烯职业危害进行了动态观察。结果证明氯乙烯肝脏损害与车间浓度、年龄、工龄有关(P<0.05),与工种无关;三年间断肝功化验,无转氨酶增高者,提示肝脏损害以慢性纤维化为主,这点与传染性肝炎不同;未发现肝血管肉瘤及癌变,无指端溶骨症。一例双指呈囊样改变,是否为指端溶骨症的早期改变,有待进一步观察。
From 1981 to 1983, the production conditions of vinyl chloride workshop in a chemical plant were improved so that the concentration of vinyl chloride in the air of the workshop basically reached the national maximum allowable concentration (30mg / m ~ 3), and the occupational hazards of vinyl chloride before and after the improvement were Dynamic observation. The results showed that the liver damage of vinyl chloride was related to the plant concentration, age and length of service (P <0.05), not related to the type of work; three years of liver function tests, no transaminase increased, suggesting that liver damage mainly chronic fibrosis, and this infection Hepatitis is different; no hepatic angiosarcoma and carcinogenesis, no finger osteolytic disease. A case of two-finger cystic change, whether the early end of osteolytic changes, pending further observation.