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目的：观察兔失血性休克时一氧化氮(NO)、去甲肾上腺素(NE)和肾上腺素(E)的变化及其在休克发展中的作用。方法：24只家免随机分为休克组和对照组，每组12只。休克组经股动脉放血至MAP达6．67kPa，维持30分钟后于0．5、1、3及6小时采血，测定NO2-、NE和E的水平，对照组于相应时点采血测定上述指标。结果：休克组在实验后各时点的NO2-、NE及E水平均较实验前及对照组相应时段明显升高(P<0．05)。结论：休克时NO生成增加，使血管进一步扩张，加重休克；NO降低了血管对儿茶酚胺的缩血管反应，使休克难于纠正。“,”Objective:To study the changes of nitric oxide(NO), epinephrine(E) and norepinephrine (NE) and their ef-fects on the development of shock. Methods: Twenty-four rabbits were divided into 2 groups: Shock group( n = 12) and con-trol group (n = 12). The shock state (MAP = 6.67kPa)was induced by controlled bleeding and maintained for 30 min. Blood samples were drawn at 0.5, 1, 3 and 6 hour for measurements of NO2-E and NE. In control group, the blood samples were taken and measured at the corresponding intervals. Results: After shock, the level of NO2-, E and NE at each time-point wasrnobviously higher in shock group than that of preshock and control group (P < 0.05). Conclusion:In shock state, the level ofNO is increased, resulting in vaso-dilation and decrease sensitivity of vessel to catecholamines.