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目的：探讨肾细胞癌（肾癌）微血管密度与癌细胞转移的相关性，以寻找判断肾癌细胞转移的可靠指标。方法：用第八因子相关抗原（F8因子）的单克隆抗体对32例肾癌石蜡切片行免疫组织化学染色，计数200倍视野内染色的微血管数（即做血管密度）。根据临床和术后病理检查是否存在癌细胞转移将患者分为两组。结果：有癌细胞转移者平均微血管密度为76±29，无癌细胞转移者为44±20，两者间有显著性差异（P＜0．05）；logistic回归分析表明做血管密度与癌细胞转移有相关性。结论：微血管密度可作为判断肾癌转移的可靠指标。
Objective: To investigate the correlation between microvessel density and metastasis of renal cell carcinoma (renal carcinoma) in order to find a reliable index for judging the metastasis of renal cell carcinoma. Methods: 32 cases of kidney cancer paraffin sections were immunohistochemically stained with a monoclonal antibody against the eighth factor-associated antigen (F8 factor), and the number of microvessels stained in the 200-fold field of view (ie, vessel density) was counted. Patients were divided into two groups according to clinical and postoperative pathological examinations for the presence of cancerous metastases. Results: The average microvessel density was 76±29 in cancer metastasis patients and 44±20 in those without cancer metastasis. There was a significant difference between the two (P<0.05); logistic regression analysis showed that blood vessel density and cancer cells The transfer has relevance. Conclusion: Microvessel density can be used as a reliable indicator to determine the metastasis of renal cancer.