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对22例与输血有关的非甲、非乙型肝炎病人和2例实验诱发患病的黑猩猩的一系列血清标本,用 RaJi—细胞放射免疫法检测了循环免疫复合物。13例病人(59%)和1例黑猩猩,在转氨酶恢复之前,恢复时期及恢复至正常时均有循环免疫复合物。患慢性非甲、非乙型肝炎的10人中,7人有可查到的复合物。其水平高低与血清转氨酶变化相一致。免疫复合物可能包含和复盖有病毒抗原。而它们的存在可以解释常规免疫技术分离毒抗原失败的原因。
A series of serum samples of 22 blood transfusion-related non-A and non-B hepatitis patients and 2 experimental chimpanzees were tested for circulating immune complexes by Raji-cell radioimmunoassay. Thirteen patients (59%) and one chimpanzee had circulating immune complexes before, during, and after normalization of the transaminase. Of the 10 people with chronic non-A, non-B hepatitis, seven were found to be complex. The level of serum aminotransferase changes consistent. Immune complexes may contain and be covered with viral antigens. And their existence can explain the reason why the conventional immunization technique failed to separate the virulent antigens.