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阿糖腺甙(Vidarabine)或腺嘌呤阿糖甙(Adeninearadinoside)是腺甙类似物,常用于各种病毒(包括单纯性疱疹、带状疱疹、乙型肝炎和巨细胞病毒)感染。其最常见的毒性有恶心、呕吐、体重下降、无力、巨幼细胞病、震颤和血栓性静脉炎。文献中曾报导过5例阿糖腺甙引起的脑病,最近作者又发现2例。例1,58岁,男,因带状疱疹、带状疱疹性脊髓炎入院,用皮质类固醇治疗无效,改用阿糖腺甙15mg/kg/日,静注,同时还用其他解热、镇痛、安定剂。两天后出现谵妄、嗜睡、精神混浊、定向力障
Vidarabine or Adeninearadinoside is an adenosine analogue commonly used in the infection of various viruses, including herpes simplex, shingles, hepatitis B and cytomegalovirus. The most common toxicities are nausea, vomiting, weight loss, weakness, megaloblastic disease, tremor and thrombophlebitis. The literature has reported 5 cases of adenosine induced encephalopathy, the authors also found two cases. Example 1,58 years old, male, admitted for herpes zoster, herpes zoster myelitis, corticosteroid therapy ineffective, with glycosides adenosine 15mg / kg / day, intravenous injection, but also with other antipyretic, the town Pain, tranquilizer. Two days later, delirium, drowsiness, confusion, and immobility were observed