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目的：研究血清涎酸（SA）对食管癌诊断及监测的临床价值。方法：采用HondaS改良的荧光测定法，对107例食管癌，83例良性疾病患者和103例健康人进行血清SA测定。结果：食管癌组患者血清SA含量显著高于良性疾病组和健康人组（P＜0．01）；不同组织类型和临床分期的食管癌患者血清SA水平间也有明显差异，血清SA水平与肿瘤的去分化程度和临床分期成正比关系；食管癌根治术4周后的血清SA水平显著低于术前（P＜0．01）；食管癌复发或有转移，则血清SA会再次明显升高或持续在高水平。结论：血清SA的测定对食管癌诊断。疗效观察及术后监测具有显著的临床价值。
Objective: To study the clinical value of serum citrate (SA) in the diagnosis and monitoring of esophageal cancer. Methods: The serum SA was measured in 107 cases of esophageal cancer, 83 cases of benign disease, and 103 healthy subjects using HondaS modified fluorescence assay. Results: Serum SA levels in esophageal cancer patients were significantly higher than those in benign diseases and healthy subjects (P<0.01). There were also significant differences in serum SA levels in different tissue types and clinical stages of esophageal cancer patients. Serum SA levels and tumors There was a positive relationship between dedifferentiation and clinical stage; serum SA levels after radical resection of esophageal cancer were significantly lower than before surgery (P<0.01); recurrent or metastatic esophageal cancer resulted in a marked increase in serum SA. Or continue at a high level. Conclusion: The determination of serum SA is useful for the diagnosis of esophageal cancer. Efficacy observation and postoperative monitoring have significant clinical value.