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近十年来万古霉素的应用,经历了戏剧性的改变,特别是对甲氧西林耐药菌感染治疗的临床效果显著.目前的研究注意到万古霉素在病人中的分布性质、评价血清浓度与其有害作用间的相互关系.虽然,万古霉素在肠胃道吸收完全,但应重视近来报道的其血清浓度随着口服给药对伪膜性肠炎有潜在的危险.万古霉素非肠道给药时的分布,是一种最好的3指数模型,其初期相半衰期(t_(1/2)x)约7min,第2相约
Vancomycin has undergone drastic changes in the last decade, especially clinically effective for the treatment of methicillin-resistant infections The present study noted the distributional nature of vancomycin in patients and the relationship between serum concentrations and Although Vancomycin is completely absorbed in the gastrointestinal tract, attention should be paid to the recent reports that its serum concentration is potentially dangerous to pseudomembranous colitis with oral administration. Vancomycin is administered parenterally When the distribution is the best 3 index model, the initial phase half-life (t_ (1/2) x) about 7min, the second phase is about