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1979年以来,有关人肿瘤细胞癌基因的研究发展迅速,其中研究最多的为ras癌基因家族(包括K-ras、H-ras、N-ras)。ras癌基因通常由12、13及61位密码的点突变而激活,ras癌基因编码由188～189个氨基酸组成的P_(21)蛋白质,该蛋白质定位于细胞膜,在细胞的生长及分化过程中参于信号的传递系统。细胞内ras癌基因突变后,ras蛋白质的稳定性增加,则引起持续的信号传递,最终导致细胞的恶性转化。不同肿瘤的ras癌基突变率不同,有关妇科肿瘤ras癌基因突变的研究尚少,本文研究目的为检测子宫内膜癌ras癌基点突变发生率。 此研究包括45例子宫内膜癌,其中32例腺癌、
Since 1979, there has been a rapid development of oncogene research on human cancer cells, of which the ras oncogene family (including K-ras, H-ras and N-ras) is the most studied. The ras oncogene is normally activated by site-directed mutagenesis at codons 12, 13, and 61. The ras oncogene encodes a P21 protein consisting of 188 to 189 amino acids. This protein is localized in the cell membrane during cell growth and differentiation Reference signal transmission system. After the intracellular ras oncogene mutation, ras protein stability increases, then leads to sustained signal transmission, eventually leading to malignant transformation of cells. Different cancer ras oncogene mutation rate is different, gynecologic oncology ras oncogene mutation research is still small, the purpose of this study is to detect the incidence of endometrial cancer ras. This study included 45 cases of endometrial cancer, of which 32 cases of adenocarcinoma,