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伯基特淋巴瘤为恶性淋巴瘤的特殊型,1958年Burkitt根据收集的58例作了系统的报道。本病集中于非洲热带潮湿地区,多害及儿童,故又称为非洲儿童恶性淋巴瘤,除流行于非洲大陆外,也散发于其它非流行区。近年来上海、北京、四川、新疆等地区亦有散在发生,国内个例报道曾见19例。综合此前国内报告的19例,男13,女6,年龄最小2岁11个月,最大72岁,中位年龄21岁,0-14岁儿童9例(50％)。侵犯部位,单纯颌骨破坏8例(42％),腹内(腹膜后、胃肠道、胰脾等)6例(32％),颌面及腹部同时受累1例(5％),浅表淋巴结受累3例(16％),纵隔1例(5％)。侵犯颌骨致溶骨性破坏,面部无疼性肿物很少见溃烂。肿物生长迅速,腹部病变常以肠梗阻、肠套叠、肠扭转等急诊就医,发病后就医时间10天-4个月。综合19例中,除1例生存16个月外,均在半年内死亡。病例介绍见表1。讨论病因伯基特淋巴瘤病因已公认为疱疹病毒。非洲流行区病例中,患者血清内抗EB病毒的VCA抗体的滴度全部阳性,而高滴度的(1:640)阳性
Burkitt’s lymphoma is a special type of malignant lymphoma. In 1958, Burkitt reported systematically on the basis of collected 58 cases. The disease is concentrated in tropical and humid areas of Africa, more harm and children, it is also known as African children with malignant lymphoma, in addition to the continent in Africa, but also distributed in other non-endemic areas. In recent years, Shanghai, Beijing, Sichuan, Xinjiang and other regions also occur randomly, with 19 cases reported in China. According to previous reports from China, 19 cases were males and 13 females, the youngest was 2 years and 11 months, the oldest was 72 years old, the median age was 21 years old and the children aged 0-14 years were 9 cases (50%). 6 cases (32%) were intra-abdominal (retroperitoneum, gastrointestinal tract, pancreatic spleen, etc.), 1 case (5%) had maxillofacial and abdominal discomfort, superficial Lymph node involvement in 3 cases (16%), mediastinal in 1 case (5%). Invasion of jaw caused by osteolytic destruction, facial painless tumor rarely ulceration. Rapid growth of the tumor, abdominal lesions often intestinal obstruction, intussusception, intestinal torsion and other emergency medical treatment, medical treatment time after onset of 10 days -4 months. Among the 19 cases, all except one survived for 16 months, all died within six months. Case description in Table 1. Discussion The etiology of Burkitt’s lymphoma has been recognized as a herpesvirus. In cases of endemic areas in Africa, the titer of anti-EBV VCA antibodies in the sera of patients was all positive, whereas high titers (1: 640) were positive