【摘 要】
：
The occurrence of cardiac arrhythmias is related to the abnormality of ion channels not only in sarcolemma but also in the sarcoplasmic reticulum, which regulat
【机 构】
：
Research Division of Pharmacology,China Pharmaceutical University,Nanjing 210009,China
论文部分内容阅读
The occurrence of cardiac arrhythmias is related to the abnormality of ion channels not only in sarcolemma but also in the sarcoplasmic reticulum, which regulates the process of calcium release and up-take intracellularly. Pattes of ion channelopathy in the sarcolemma can be divided into single channel disorder from gene mutations and multiple channels disorder in a diseased hypertrophied heart. Abnormal RyR2, FKBP12.6, SERCA2a, and PLB are also involved in the initiation of cardiac arrhythmias. Maladjustment by hyperphosphorylation on the ion channels in the sarcolemma and RyR2-FKBP12.6 and SERCA2a-PLB is discussed. Hyperphosphorylation, which is the main abnormality upstream to ion channels, can be targeted for suppressing the deterioration of ion channelopathy in terms of new drug discovery in the treatment and prevention of malignant cardiac arrhythmias.
其他文献
Aim: To establish a cell-based assay to screen human dopamine D1 and D5 receptor agonists against compounds from a natural product compound library.Methods: Syn
Aim: To determine the Ca2+ source and cellular mechanisms of spontaneous Ca2+ oscillations in hippocampal astrocytes. Methods: The cultured cells were loaded wi
目的探讨软组织透明细胞肉瘤(CCS)的临床病理特征与治疗方法。方法对我院既往诊治的15例CCS患者的临床病理学资料进行回顾性分析,并复习文献。结果男性8例,女性7例,平均年龄3
Aim: To investigate the effect of ginsenoside Rg1, an effective ingredient from ginsenoside, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subs
花粉及花药发育是植物发育生物学的一个重要研究领域。在高等植物的小孢子发生发育及花粉成熟过程中，涉及到大量基因的协同表达，其中某个基因的结构或表达发生变异，都将导致雄性不育。很多高等植物中都存在着雄性不育现象，对雄性不育突变体的研究，不仅有助于了解植物的生殖规律，更重要的是它具有潜在的农业应用价值，如雄性不育的利用。1996年，四川农业大学玉米研究所通过太空诱变处理川单9号种子获得了一份雄性不育突变
干旱、盐碱等非生物逆境是制约农业生产最主要的因素之一。特别对于我国的小麦生产,由于北方小麦主产区大多处在干旱、半干旱地区,农业用水和生活用水的矛盾十分突出,因此,改良主栽小麦品种的抗旱性对于小麦生产具有重要的意义。本研究采用基因枪法将来自于大豆、棉花的GmDREB1和GhDREB基因转化山东主栽品种济麦19、20,获得再生植株256株。T0、T1代PCR检测证实基因可以稳定遗传,其中部分转基因植株
干旱是影响水稻生产的重要逆境之一，随着全球水资源的短缺和粮食危机的加剧，培育节水抗旱杂交稻具有广阔的应用前景。一般水稻栽培品种的异交结实率低，为提高杂交制繁种产量，需要选育高异交结实率的不育系，其中柱头外露率是解决这一问题的关键因素之一。本研究利用来源于沪旱1B／Ⅱ-32B和沪旱1B／K17B的两个F2群体，对水稻柱头外露率的遗传机制进行了研究，主要结果如下1利用沪旱1B／Ⅱ-32B为两亲本的F_
Aim: To explore the relationship between differential leucocyte count and coronary atherosclerosis. Methods: The study population consisted of 507 consecutive p
烤烟的外观和内在品质受多种因素的综合影响。从植物营养的角度而言,镁、锌、硼等营养元素对植物生长发育的作用早已被人们所认识。虽然目前有关这三种营养元素对烤烟品质的
目前我国水果生产中，柑桔是仅次于苹果的第二大水果，在我国南方农村产业结构中有举足轻重的地位。柑桔也是重庆市栽培的重要水果。采后技术专家估计，全世界每年生产的新鲜水果蔬