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非风湿性心房颤动(房颤)的发病率60岁以上者年增0.5％,脑卒中年发生率3.8％。华法林治疗后栓塞年发生率1.6％,而配对安慰剂组为8.3％。阿司匹林治疗后栓塞年发生率3.2％,配对安慰剂组为6.8％,但对75岁以上者无防治效果。因此作者主张器质性心脏病伴慢性房颤者接受低强度华法林治疗,治疗组年出血率1.7％,其中颅内出血占0.4％。
The incidence of non-rheumatic atrial fibrillation (atrial fibrillation) over the age of 60 years increased by 0.5% annual incidence of stroke was 3.8%. The annual incidence of embolism after warfarin treatment was 1.6%, compared with 8.3% for the matched placebo group. The annual incidence of embolism after aspirin treatment was 3.2% and in the placebo group 6.8%, but no effect was observed in patients over 75 years of age. Therefore, the author claims that patients with organic heart disease and chronic atrial fibrillation receive low-intensity warfarin therapy, with an annual bleeding rate of 1.7% in the treatment group, with intracranial hemorrhage accounting for 0.4%.