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目的了解珠江三角洲的广州、深圳、东莞、佛山4个市流动儿童口服脊髓灰质炎(脊灰)减毒活疫苗(OPV)预防接种现状及影响因素,为制定流动儿童免疫策略提供科学依据。方法对这4个市本地和外来儿童进行了脊灰抗体水平检测,应用Foxpro 5.0建立数据库,SPSS软件进行统计分析。结果共检测1 180名0~6岁儿童的血标本,其中本地儿童595名,脊灰Ⅰ、Ⅱ、Ⅲ型抗体阳性率分别为99.50%、99.16%、98.15%,几何平均滴度(GMT)Ⅰ、Ⅱ、Ⅲ型分别为1∶217、1∶214、1∶73;外来儿童585名,脊灰Ⅰ、Ⅱ、Ⅲ型抗体阳性率分别为94.53%、98.12%、94.53%,GMTⅠ、Ⅱ、Ⅲ型分别为1∶145、1∶193、1∶58。显示外来儿童和本地儿童的脊灰抗体阳性率和GMT均在较高水平。结论广东省通过OPV常规免疫和强化免疫,已形成对脊灰病毒有效的免疫屏障。但外来儿童的脊灰抗体阳性率和GMT均低于本地儿童,因此应加强对流动人口儿童的免疫规划管理。
Objective To understand the current status and influencing factors of vaccination against oral poliomyelitis (poliovirus) in migrating children in four cities of Guangzhou, Shenzhen, Dongguan and Foshan in the Pearl River Delta, and to provide a scientific basis for formulating immunization strategies for migrant children. Methods Polymorphonuclear antibodies were detected in local and foreign children in these four cities. The database was set up with Foxpro 5.0 and SPSS software was used for statistical analysis. Results A total of 1 180 blood samples were collected from 0 to 6 years old children, including 595 local children and 99.50%, 99.16% and 98.15% respectively of the poliovirus types Ⅰ, Ⅱ and Ⅲ. The geometric mean titers (GMT) The positive rates of type Ⅰ, Ⅱ and Ⅲ antibodies were 94%, 98.12% and 94.53%, respectively. The positive rates of GMT Ⅰ, Ⅱ and Ⅲ were 1: 217, 1: 214 and 1: , Type Ⅲ were 1:145,1:193,1:58 respectively. Poliovirus positive rates and GMTs were higher in both foreign and local children. Conclusion In Guangdong, OPV routine immunization and intensive immunization have formed an effective immune barrier against poliovirus. However, the positive rates and GMTs of poliovirus among foreign children are lower than that of local children, so the immunization planning and management of migrant children should be strengthened.