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用放射免疫技术测定哮喘豚鼠血浆及支气管肺泡准洗液（BALF）中内皮素-1（ET-1）、心钠素（ANF）及环磷鸟苷（cGMP）含量。结果显示哮喘组血浆及BALF中ET－1、ANF、cGMP含量均显著高于正常对照组；ET－1含量与ANF含量变化呈负相关，而ANF含量与cGMP含量变化呈正相关。提示ET－1在哮喘发病中起重要作用；ANF负反馈抑制ET－1的合成与释放；外源性ANF可能成为治疗哮喘的一种新方法。
The contents of ET-1, ANF and cGMP in asthmatic guinea pig plasma and bronchoalveolar allantoic fluid (BALF) were measured by radioimmunoassay. The results showed that the levels of ET-1, ANF and cGMP in plasma and BALF of asthma group were significantly higher than those of normal control group. The content of ET-1 was negatively correlated with the change of ANF content, while the content of ANF was positively correlated with the content of cGMP. Suggesting that ET-1 plays an important role in the pathogenesis of asthma. ANF negative feedback inhibits the synthesis and release of ET-1. Exogenous ANF may be a new treatment for asthma.