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本文介绍了一种新型的成年大鼠（5－8周龄）纵切脊髓片模型．此模型与传统的横切脊髓片的不同之处是可带有多条长达10mm的后根．在体视显微镜下骶髓后连合该（DCN）为一条透明的灰质带，极易与后角其它部位区分，因此最适合于对DCN神经元的研究．应用盲膜片钳全细胞记录法，在此模型上研究了DCN神经元自发的和后根刺激诱发的兴奋性突触后电位（EPSPs）．自发的和后根刺激诱发的快EPSPs主要由非NMDA谷氨酸受体介导；后根刺激诱发的促EPSPs由NMDA受体（或／和）P物质受体介导．此模型可用于初级传入信息在DCN内的突触传递机理以及相邻阶段间初级传入信息的相互作用的研究。
This article describes a novel longitudinal rat spinal cord model of adult rats (5-8 weeks old). The difference between this model and the traditional transection of the spinal cord is that it can have multiple posterior roots up to 10 mm in length. The sacrococcygeal posterior commissure (DCN) under a stereo microscope is a clear gray-like zone that is easily distinguished from other parts of the posterior horn and is therefore best suited for the study of DCN neurons. Using a patch-clamp whole-cell recording method, excitatory postsynaptic potentials (EPSPs) induced by both spontaneous and post-root stimulation of DCN neurons were studied. The fast EPSPs induced by spontaneous and post-root stimulation are mainly mediated by non-NMDA glutamate receptors; the post-root stimulation-induced EPSPs are mediated by NMDA receptor (or / and) substance P receptors. This model can be used for the study of the synaptic transmission mechanism of primary afferent information in DCN and the interaction of primary afferent information between adjacent stages.