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咳喘膏,经天津市咳喘膏临床协作组多年来反复验证,证实对防治慢性气管炎有一定效果,但对其药理作用尚未进行研究。本实验目的在于通过动物实验,观察其作用原理,配合临床改进剂型,提高疗效。临床协作组曾发现在病人背部穴位涂抹咳喘膏主药之一洋金花提取液时不仅有平喘作用,而且有烦躁不安,视力障碍等副作用。因此,本实验以洋金花的主要有效成份东莨菪硷为实验材料,以小鼠的扩瞳反应和豚鼠的止喘效果为指标,对咳喘膏的经皮吸收作用和穴位作用进行了初步观察。
Kechuang cream, cough cream by Tianjin Clinical Cooperative Group repeatedly verified over the years, confirmed the prevention and treatment of chronic bronchitis have some effect, but its pharmacological effects have not been studied. The purpose of this experiment is to observe the action principle through animal experiments, and to improve the efficacy with the clinical improvement of dosage forms. Clinical collaborative group has found that in the back of the patient smear cough cream one of the main drug when the Yang Jinhua extract not only have asthma effect, but also irritability, visual impairment and other side effects. Therefore, in this experiment, the main active ingredient of the genus Camellia as the experimental material, the mouse pupil dilation reaction and guinea pig anti-asthmatic effect as an indicator of Kechuan cream percutaneous absorption and acupuncture effect was preliminary Observed.