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喹诺酮(QNS)应用已30年,80年代新合成第三代即氟喹酮(F-QNS)后发展更为迅速,为抗菌治疗带来方便,但也提出一些课题。目前,临床广为应用的有氟哌酸,环丙氟哌酸,而且疗效可靠。下面就QNs的特点抗菌活性等方面作一综述。1 ONS的特点1.1化学合成发展迅速。目前已进入临床或临床前开发者共约50个。1.2抗菌谱广、药物动力学理想。F-ONS对G-球菌特别是G-杆菌活性好,能渗入组织、体腔并进入细胞
Quinolone (QNS) has been used for 30 years. After the third generation of F-QNS, which was synthesized in the 1980s, fluoroquinolone (F-QNS) developed rapidly and brought convenience for antibacterial therapy. However, some questions were also raised. At present, widely used in clinical norfloxacin, ciprofloxacin, and reliable. Below on the characteristics of QNs antimicrobial activity and so on to make a review. 1 ONS features 1.1 The rapid development of chemical synthesis. Currently has entered a total of about 50 clinical or preclinical developers. 1.2 wide antibacterial spectrum, ideal pharmacokinetics. F-ONS on G-coccus especially G-bacteria activity, can penetrate into the tissue, body cavity and into the cells