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目的观察无创正压通气法在治疗COPD并II型呼吸衰竭的应用。方法对我科2007年1月至2009年6月住院的50例COPD伴Ⅱ型呼吸衰竭的患者在相关基础治疗的基础上,予无创正压通气(NIPPV)。观察治疗前后24h的动脉血气分析结果以及心率、呼吸频率和血压的变化。结果NIPPV治疗24h后,患者的心率显著降低,pH、PaCO2和PaO2明显改善,比较差异均有统计学意义(P<0.05),而且未见严重的不良反应发生。结论NIPPV治疗COPD伴Ⅱ型呼吸衰竭患者疗效肯定,缩短病程,能显著降低COPD伴Ⅱ型呼吸衰竭患者的死亡率。
Objective To observe the application of non-invasive positive pressure ventilation in the treatment of COPD and type II respiratory failure. Methods Fifty patients with COPD and type Ⅱ respiratory failure admitted to our department from January 2007 to June 2009 were treated with noninvasive positive pressure ventilation (NIPPV) on the basis of related basic therapy. Arterial blood gas analysis was observed 24h before and after treatment as well as heart rate, respiratory rate and blood pressure changes. Results After treatment with NIPPV for 24 hours, the heart rate of patients was significantly decreased, and the values of PaCO2 and PaO2 were significantly improved. The differences were statistically significant (P <0.05), but no serious adverse reactions occurred. Conclusion NIPPV treatment COPD with type Ⅱ respiratory failure patients with positive effect, shorten the course of the disease, can significantly reduce COPD with type Ⅱ respiratory failure mortality.