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目的:探讨抑癌基因P16与卵巢癌生物学行为的关系及在卵巢癌中表达的临床意义。方法:采用S-P免疫组织化学方法,检测19例卵巢癌,10例正常卵巢组织中抑癌基因P16的表达,结果:19例卵巢癌,P16检出率为632%,3例晚期卵巢癌表达阴性,4例Ic期以上低分化卵巢癌表达弱阳性,正常对照组,80%阳性表达,10%弱阳性表达。研究提示:P16的突变与缺失可能与卵巢癌的发生发展密切相关,与临床分期、病理分级密切相关。
Objective: To investigate the relationship between tumor suppressor gene P16 and biological behavior of ovarian cancer and its clinical significance in ovarian cancer. Methods: SP immunohistochemistry was used to detect the expression of tumor suppressor gene P16 in 19 cases of ovarian cancer and 10 cases of normal ovarian tissue. Results: In 19 cases of ovarian cancer, the detection rate of P16 was 632%, and 3 cases of advanced ovarian cancer were negative , 4 cases of poorly differentiated ovarian cancer Ic above expression was positive in normal control group, 80% positive expression, 10% weakly positive expression. The study suggests that the mutation and deletion of P16 may be closely related to the occurrence and development of ovarian cancer, which is closely related to clinical stage and pathological grade.