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作者对114例伴有高血压和/或蛋白尿的妊娠妇女,分娩后8天作肾活检、光镜和/或电子显微镜及免疫荧光检查,其中41例都用上述三法进行检查。根据病人临床标准分成6组,第1、2组(52例)显示典型先兆子痫的临床症状和病理特征,其余4组(62例)只有单纯性高血压,这些病人中42例有肾脏病变,类似先兆子痛,同时有持续性高尿酸血症。临床病理学关系:典型妊娠肾病(PIN)肾小球损害,包括内皮肿胀,有些毛细血管襻出现双重轮廓,在内皮下和系膜区有致密沉积物,可被纤维蛋白相关抗原(FRA)和免疫球蛋白抗血清染色。作者指出①PIN损害经常在单纯高血压的妊娠期见到。②典型PIN加上原先存在的肾病病人,仍容易鉴别。
The authors of 114 pregnant women with hypertension and / or proteinuria performed renal biopsy, light microscopy and / or electron microscopy and immunofluorescence 8 days after delivery, of which 41 were examined by the above three methods. The patients were divided into 6 groups according to their clinical criteria. Groups 1 and 2 (52 cases) showed clinical symptoms and pathological features of typical preeclampsia. The remaining 4 groups (62 cases) had simple hypertension and 42 of these patients had nephropathy , Similar to preeclampsia, with persistent hyperuricemia. Clinical Pathology Relationship: Typical geriatric nephropathy (PIN) glomerular lesions, including endothelial swelling, some capillary loops with a double profile, dense deposits in the subendothelial and mesangial areas, fibro-related antigens (FRA) and Immunoglobulin antiserum staining. The authors point out that ① PIN damage often seen in hypertensive pregnancy. ② typical PIN plus existing kidney disease patients, still easy to identify.