论文部分内容阅读
目的观察丙基硫氧嘧啶在甲状腺功能亢进症治疗中的疗效与不良反应。方法选取我科收治的初次确诊且未经治疗的轻中度甲状腺功能亢进症患者共68例,分初治期、减量期、维持量期三个阶段服用丙基硫氧嘧啶,疗程1.5～2a。疗程中除非有较严重反应,一般不宜中断,并定期随访。定期复查甲状腺功能,调整用药。停药指标:甲状腺肿消失或明显减小;血清FT3、FT4和TSH连续3个月正常;血TRAb浓度明显下降或转阴。结果本组长期缓解率33(55%)例;复发率26例(43.3%);无效1例;失访8例。不良反应白细胞减少2例(2.9%);皮疹1例(1.5%)肝功能受损2例(2.9%)。结论丙基硫氧嘧啶在甲状腺功能亢进症的治疗中是有效的,长期用药及长期的随访是必需的。常见不良反应为皮疹及白细胞减少。
Objective To observe the efficacy and adverse reactions of propylthiouracil in the treatment of hyperthyroidism. Methods A total of 68 patients with mild to moderate hyperthyroidism who were initially diagnosed and untreated in our department were enrolled. Propylthiouracil was administered in three stages: initial treatment, reduction and maintenance. The course of treatment was 1.5 ~ 2a. Unless there is a more serious reaction in the course of treatment, the general should not be interrupted, and regular follow-up. Regular review of thyroid function, adjust medication. Discontinuation indicators: Goiter disappeared or significantly reduced; serum FT3, FT4 and TSH normal for 3 months; blood TRAb concentrations decreased significantly or negative. Results The long-term response rate was 33 (55%) in this group. The recurrence rate was 26 (43.3%), 1 was ineffective and 8 patients were lost. Adverse reactions leukopenia in 2 cases (2.9%); rash in 1 case (1.5%) impaired liver function in 2 cases (2.9%). Conclusion propylthiouracil in the treatment of hyperthyroidism is effective, long-term medication and long-term follow-up is required. Common adverse reactions are rash and leukopenia.