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目的 :观察鼓室内注射庆大霉素治疗梅尼埃病的疗效和副作用。方法 :对 13例单侧梅尼埃病患者行患侧鼓室内注射庆大霉素 0 .5ml(2 6 .7g/L) ,每周 1次 ,共 2次 ,随访 2年以上。采用 1996年上海会议制定的梅尼埃病诊断依据及疗效分级标准诊断及判定疗效。结果 :治疗后 18～ 2 4个月 ,眩晕完全或基本控制 12例 ,有效率为 92 .3%。治疗后 2周 ,0 .5kHz、1.0kHz、2 .0kHz和 3.0kHz平均听阈较治疗前无明显变化 ;8.0kHz听阈升高 3例 (2 3.1% ) ;治疗后 18～ 2 4个月 ,0 .5kHz、1.0kHz、2 .0kHz和 3.0kHz平均听阈提高 4例 (30 .8% ) ,8.0kHz提高 5例 (38.5 % ) ,耳鸣无明显变化。结论 :鼓室注射庆大霉素是一种值得提倡的经济、简便、能有效控制梅尼埃病眩晕发作的治疗方法 ,但对听力也有一定的损坏作用 ,因此在治疗前必须向患者说明
Objective: To observe the curative effect and side effects of injection of gentamicin in Meniere’s disease. Methods: Thirteen patients with unilateral Meniere’s disease were injected intraperitoneally with 0.25 ml gentamicin (26.7 g / L) once a week for 2 years. Using 1996 Shanghai Conference to develop Meniere’s diagnosis based on diagnostic criteria and efficacy classification criteria to determine the efficacy. Results: 18 ~ 24 months after treatment, dizziness, complete or basic control in 12 cases, the effective rate was 92.3%. After 2 weeks of treatment, the average hearing thresholds at 0 .5kHz, 1.0kHz, 2.0kHz and 3.0kHz had no significant changes compared with those before treatment; the hearing threshold at 8.0kHz increased in 3 cases (23.1%); after 18-24 months The mean hearing threshold was improved in 4 cases (30.8%) at 5kHz, 1.0kHz, 2.0kHz and 3.0kHz, and increased in 5 cases (38.5%) at 8.0kHz. There was no significant change in tinnitus. CONCLUSION: Tympanic injection of gentamicin is an economical, simple and effective method to control the onset of Meniere’s disease. However, it also has a certain damaging effect on the hearing. Therefore, patients must be explained before treatment