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目的研究sCD30与急性排斥反应的相关性。方法采用sCD30ELISA试剂盒(双抗体加心法)对58例首次肾移植患者术前1d、术后7d、28d进行了sCD30检测,31例健康者与术前1dsCD30做对照,并记录排斥反应的发生率。结果肾移植术前1dsCD30水平与急性排斥反应的相关性为X2=4.843,P<0.05,有显著性差异。肾移植术后第7天sCD30水平与急性排斥反应的相关性为X2=7.201,P<0.01,有高度显著性差异。肾移植术后第28天sCD30水平与急性排斥反应的相关性为X2=2.095,P<0.05,没有显著性差异。结论sCD30的高表达与急性排斥反应有关,sCD30在急性排斥反应中可能扮演了重要的角色。
Objective To study the correlation between sCD30 and acute rejection. Methods sCD30 ELISA kit (double antibody plus heart method) 58 cases of primary renal transplant patients 1d before surgery, 7d, 28d after sCD30 detection, 31 healthy controls and preoperative 1dsCD30, and record the occurrence of rejection rate. Results The correlation between 1ds CD30 level before acute kidney transplantation and acute rejection was X2 = 4.843, P <0.05, with significant difference. The correlation between sCD30 level and acute rejection on the 7th day after kidney transplantation was X2 = 7.201, P <0.01, with a highly significant difference. The correlation between sCD30 level and acute rejection on the 28th day after kidney transplantation was X2 = 2.095, P <0.05, there was no significant difference. Conclusion The high expression of sCD30 is associated with acute rejection and sCD30 may play an important role in acute rejection.