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目的观察奥美拉唑钠和阿莫西林联合治疗消化性溃疡患者的治疗效果。方法对120例(治疗组)消化性溃疡患者用奥美拉唑40mg+生理盐水100mL中,一日两次,静脉滴注。另118例(对照组)用法莫替丁20mg+生理盐水100mL一日两次,静脉滴注。两组治疗期间同时给予阿莫西林0.5g,一日三次,饭前口服,比较两种抗酸药和阿莫西林配伍时治疗Hp阳性消化性溃疡的疗效。结果治疗组与对照组对消化性溃疡愈合的治疗有效率分别为84.17%、50.85%,两组治疗有效率比较差异有统计学意义(P<0.05);Hp根除率分别为72.53%、27.12%,两组Hp根除率比较差异有统计学意义(P<0.05)。结论奥美拉唑和阿莫西林联合治疗幽门螺旋杆菌阳性消化性溃疡具有疗效高、费用低,值得基础医院应用。
Objective To observe the therapeutic effect of omeprazole sodium and amoxicillin in patients with peptic ulcer. Methods 120 patients (treatment group) peptic ulcer patients with omeprazole 40mg + saline 100mL twice a day, intravenous drip. The other 118 cases (control group) with famotidine 20mg + saline 100mL twice a day, intravenous infusion. Amoxicillin 0.5g was given to the patients in both groups simultaneously three times a day orally before meals. The efficacy of two antacids and amoxicillin in the treatment of Hp-positive peptic ulcer was compared. Results The effective rates of treatment for peptic ulcer healing in treatment group and control group were 84.17% and 50.85%, respectively. There was significant difference between the two groups in the treatment efficiency (P <0.05); the Hp eradication rates were 72.53% and 27.12% There was significant difference in Hp eradication rate between the two groups (P <0.05). Conclusion Omeprazole and amoxicillin combined treatment of Helicobacter pylori positive peptic ulcer with high efficacy, low cost, it is worth the basis of hospital applications.