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目的探讨血清中白细胞介素-27(IL-27)早期鉴别诊断类风湿性关节炎的临床价值。方法选取2013年1月至2015年12月在本院接受诊治的96例类风湿性关节炎患者作为病例组,选取同期健康体检对象60例作为对照组,分别测定血清IL-27水平,分析IL-27与其他血清因子的关系,并采用ROC曲线分析IL-27鉴别诊断类风湿性关节炎的诊断学效能。结果病例组患者的ESR、hs-CRP、RF、IL-25、IL-27水平均显著的高于对照组,差异均具有统计学意义(P<0.05);类风湿性关节炎患者的血清IL-27水平与血清ESR、hs-CRP、RF、IL-25均呈显著的正相关性关系(P<0.05);绘制ROC曲线,选取最大曲线下面积AUC值为0.841时,对应的IL-27的临界值为98.50 pg/ml,对应的灵敏度为78.90%、特异度为72.54%。结论 IL-27早期鉴别诊断类风湿性关节炎具有一定的临床价值,并且与患者的ESR、hsCRP、RF等因子具有一定的关系。
Objective To investigate the clinical value of serum interleukin-27 (IL-27) in early differential diagnosis of rheumatoid arthritis. Methods Ninety-six patients with rheumatoid arthritis admitted to our hospital from January 2013 to December 2015 were selected as the case group. Sixty healthy subjects were selected as the control group, and the level of serum IL-27 was measured. The levels of IL -27 and other serum factors, and ROC curve analysis of IL-27 differential diagnosis of rheumatoid arthritis diagnostic efficacy. Results The serum levels of ESR, hs-CRP, RF, IL-25 and IL-27 in the patients were significantly higher than those in the control group (P <0.05). Serum IL -27 and serum ESR, hs-CRP, RF, IL-25 were significantly positive correlation (P <0.05); draw ROC curve, select the area under the maximum curve AUC value of 0.841, the corresponding IL-27 The critical value was 98.50 pg / ml, corresponding to a sensitivity of 78.90% and a specificity of 72.54%. Conclusion Early diagnosis of rheumatoid arthritis with IL-27 has some clinical value, and it has certain relationship with ESR, hsCRP, RF and other factors.