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目的探讨小剂量红霉素在先天性肠旋转不良(CMI)患儿手术后胃肠道恢复中的临床意义。方法分析2010年12月-2015年12月在右江民族医学院附属医院接受Ladd手术治疗的116例CMI新生儿的临床资料,根据术后用药方案将患儿分为A组(常规治疗+小剂量红霉素)60例和B组(常规治疗)56例两组。比较两组患儿的一般资料、临床疗效、胃肠功能恢复情况、全肠内营养达标及开始经口喂养的时间、总住院时间、并发症发生情况。结果两组患儿的一般资料差异无统计学意义(P>0.05)。A组患儿治疗后临床疗效明显优于B组,治疗后肛门开始排气、排便及肠鸣音恢复时间均短于B组。全肠内营养达标及开始经口喂养的时间、总住院时间均显著少于B组,差异均有统计学意义(P<0.01)。治疗后两组患儿均未出现任何并发症。结论采用小剂量红霉素治疗术后CMI患儿的临床疗效显著,不但可以促进患儿胃肠道功能的恢复,而且安全性较高、住院时间短,值得推广。
Objective To investigate the clinical significance of low dose erythromycin in gastrointestinal tract recovery after operation in children with congenital intestinal dysplasia (CMI). Methods The clinical data of 116 CMI newborns who underwent Ladd surgery in the Youjiang Medical College Hospital from December 2010 to December 2015 were analyzed. The patients were divided into group A (conventional treatment + small Dose erythromycin) 60 cases and group B (conventional treatment) 56 cases of two groups. The general data, clinical curative effect, recovery of gastrointestinal function, total enteral nutrition, oral feeding time, total length of hospital stay and complication were compared between the two groups. Results There was no significant difference in general data between the two groups (P> 0.05). After treatment, the clinical efficacy of group A was significantly better than that of group B. The recovery time of defecation and bowel sounds of anus was shorter than that of group B after treatment. The total enteral nutrition compliance and time to oral feeding began, and the total length of stay in hospital was significantly less than that in group B, with significant differences (P <0.01). After treatment, no complications occurred in both groups. Conclusion The clinical efficacy of low dose erythromycin in postoperative CMI patients is significant. It not only can promote the recovery of gastrointestinal function in children, but also has high safety and short hospital stay and is worth popularizing.