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目的:探讨原发性中枢神经系统淋巴瘤(PCNSL)的临床特征。方法:回顾分析10例免疫功能正常的PCNSL患者的临床资料。结果:临床表现为颅内压增高及病灶所致的局部表现。病灶单发7例,多发3例,全经手术切除病灶,病理示B细胞型非霍奇金淋巴瘤。6例术后未行放化疗出院,失访1例,随访5例,平均生存4个月。1例CHOP方案化疗1周期,生存19个月。3例行大剂量甲氨蝶呤化疗+放疗;1例生存13个月,2例至今生存,平均生存24个月,复查无异常。结论:PCNSL预后不良,单纯手术不能延长患者生存期,手术结合放化疗是目前临床首选的治疗方案。
Objective: To investigate the clinical features of primary central nervous system lymphoma (PCNSL). Methods: The clinical data of 10 PCNSL patients with normal immune function were retrospectively analyzed. Results: The clinical manifestations of intracranial pressure and focal lesions caused by local performance. Seven cases of single lesions, multiple in 3 cases, all by surgical excision of the pathology of B-cell non-Hodgkin’s lymphoma. Six patients were discharged without chemotherapy after operation, 1 patient was lost to follow-up, and 5 patients were followed up for an average of 4 months. One case of CHOP chemotherapy for 1 cycle, 19 months survival. 3 cases of high-dose methotrexate chemotherapy + radiotherapy; 1 case of survival for 13 months, 2 cases have survived so far, the average survival of 24 months, no abnormalities were found. Conclusion: The prognosis of PCNSL is poor. Survival of patients with PCNSL alone can not be prolonged. Operation combined with chemoradiotherapy is the first choice of clinical treatment.