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目的观察长托宁在有机磷中毒并呼吸衰竭(呼衰)治疗中的临床效果。方法选取2005年1月至2007年1月收治的22例有机磷中毒伴呼吸衰竭患者,采用长托宁进行治疗,与2002年12月至2004年12月所收治的18例采用传统阿托品治疗的有机磷中毒伴呼衰病人的治疗效果进行分析比较。结果发现长托宁组病人呼衰缓解率明显高于阿托品组,机械通气率及通气时间均较阿托品组为短。抢救成功率明显高于阿托品组。且在治疗过程中几乎无心率增快等副作用。结论长托宁可明显减轻中毒早期病人的呼吸抑制,减少病人机械通气率及通气时间,是治疗重度有机磷中毒伴呼吸衰竭的理想药物,值得临床推广使用。
Objective To observe the clinical effect of pendimethalin in the treatment of organophosphate poisoning and respiratory failure (respiratory failure). Methods Twenty-two patients with organophosphate poisoning and respiratory failure who were admitted to our hospital from January 2005 to January 2007 were treated with penehyclidine hydrochloride and 18 patients treated with traditional atropine from December 2002 to December 2004 Organophosphorus poisoning patients with respiratory failure were analyzed and compared. The results showed that the long-acting group of patients with respiratory distress rate was significantly higher than atropine group, mechanical ventilation and ventilation were shorter than the atropine group. Rescue success rate was significantly higher than atropine group. And in the course of treatment almost no side effects such as heart rate. CONCLUSION Penehyclidine can significantly reduce the respiratory depression in patients with early poisoning and reduce the mechanical ventilation rate and ventilation time. It is an ideal drug for the treatment of severe organophosphorus poisoning with respiratory failure and is worthy of clinical promotion.