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Ehrlich早在本世纪初就发现免疫系统具有抗肿瘤的作用,Thomas在五十年代中期论证了这一观点,Burnet于七十年代初正式提出免疫监视概念,认为机体免疫系统能够识别并通过细胞免疫机制破坏肿瘤细胞.肿瘤免疫治疗即是采用主动或被动免疫手段,干预宿主免疫应答,增强机体抗肿瘤能力.自Luckey(1980年)和Olivieri(1984年)提出低剂量辐射可诱导生物体的兴奋效应和适应性反应以来,国内外学者广泛开展了低剂量辐射与免疫的研究,并于1987年在德国法兰克福召开了“低剂量辐射与免疫系统专题讨论会”.鉴于低剂量辐射诱发的适应性可提高治疗比,其刺激增强的免疫功能对肿瘤的杀灭效应又是有益的补充,为此笔者曾根据资料提出刺激疗法这一新概念,并论证了其临床应用的可行性.本文旨在探讨其增强放疗治癌效果的免疫学基础.多年来,人们通过总结大宗的临床病例,对放疗的治癌作用已深信不疑,目前,肿瘤患者的治疗70%以上需行放疗.然而,放疗对肿瘤病人免疫功能的抑制却一直困扰着人们,文献报道:肿瘤病人放疗后,由于免疫细胞对射线敏感
Ehrlich discovered that the immune system had an anti-tumor effect as early as the beginning of this century. Thomas demonstrated this view in the mid-fifties. Burnet formally proposed the concept of immune surveillance in the early 1970s. He believed that the immune system can recognize and pass cellular immunity. The mechanism destroys tumor cells. Tumor immunotherapy is the use of active or passive immune methods to intervene in the host immune response and enhance the body’s anti-tumor ability. Since Luckey (1980) and Olivieri (1984) proposed low-dose radiation can induce the excitement of the organism Since the effect and adaptive response, scholars at home and abroad have extensively conducted studies on low-dose radiation and immunity, and in 1987 in Frankfurt, Germany, held the “Low-Dose Radiation and Immune System Symposium”. In view of low-dose radiation-induced adaptation The therapeutic ratio can be increased, and the killing effect of the enhanced immune function on the tumor is a beneficial supplement. For this reason, the author has proposed a new concept of stimulation therapy based on the data, and demonstrated the feasibility of its clinical application. Explore the immunological basis for its enhanced radiotherapy and cancer treatment. Over the years, people have reviewed the bulk of clinical cases and The role of cancer has been convinced that at present, more than 70% of cancer patients need to be treated with radiotherapy. However, radiotherapy suppresses the immune function of cancer patients has been plagued by people, the literature reports: after cancer patients with radiotherapy, due to immune cells Ray sensitive