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AIM:To explore the diagnostic value of the crossmodality fusion images provided by positron emission tomography/computed tomography(PET/CT) and contrast-enhanced CT(CECT) for pancreatic cancer(PC).METHODS:Data from 70 patients with pancreatic lesions who underwent CECT and PET/CT examinations at our hospital from August 2010 to October 2012were analyzed.PET/CECT for the cross-modality image fusion was obtained using Ture D software.The diagnostic efficiencies of PET/CT,CECT and PET/CECT were calculated and compared with each other using aχ2 test.P<0.05 was considered to indicate statistical significance.RESULTS:Of the total 70 patients,50 had PC and 20had benign lesions.The differences in the sensitivity,negative predictive value(NPV),and accuracy between CECT and PET/CECT in detecting PC were statistically significant(P<0.05 for each).In 15 of the 31patients with PC who underwent a surgical operation,peripancreatic vessel invasion was verified.The differences in the sensitivity,positive predictive value,NPV,and accuracy of CECT vs PET/CT and PET/CECT vs PET/CT in diagnosing peripancreatic vessel invasionwere statistically significant(P<0.05 for each).In 19of the 31 patients with PC who underwent a surgical operation,regional lymph node metastasis was verified by postsurgical histology.There was no statistically significant difference among the three methods in detecting regional lymph node metastasis(P>0.05for each).In 17 of the 50 patients with PC confirmed by histology or clinical follow-up,distant metastasis was confirmed.The differences in the sensitivity and NPV between CECT and PET/CECT in detecting distant metastasis were statistically significant(P<0.05 for each).CONCLUSION:Cross-modality image fusion of PET/CT and CECT is a convenient and effective method that can be used to diagnose and stage PC,compensating for the defects of PET/CT and CECT when they are conducted individually.
To explore the diagnostic value of the crossmodality fusion images provided by positron emission tomography / computed tomography (PET / CT) and contrast-enhanced CT (CECT) for pancreatic cancer (PC). METHODS: Data from 70 patients with pancreatic lesions who underwent CECT and PET / CT examinations at our hospital from August 2010 to October 2012were analyzed. PET / CECT for the cross-modality image fusion was obtained using Ture D software. The diagnostic efficiencies of PET / CT, CECT and PET / CECT were calculated Of the total 70 patients, 50 had PC and 20 ben benign lesions. The differences in the sensitivity, negative predictive value (NPV), and accuracy Between CECT and PET / CECT in detecting PC were significantly (P <0.05 for each). In 15 of the 31patients with PC who underwent a surgical operation, peripancreatic vessel invasion was verified. These differences in the sensitivity, posit ive predictive value, NPV, and accuracy of CECT vs. PET / CT and PET / CECT vs. PET / CT in diagnosed peripancreatic vessel invasionwere statistically significant (P <0.05 for each). In 19 of the 31 patients with PC who underwent a surgical operation, regional lymph node metastasis was verified by postsurgical histology. There was no significant significant difference among the three methods in detecting regional lymph node metastasis (P> 0.05 for each). In 17 of the 50 patients with PC confirmed by histology or clinical follow-up , distant metastasis was recognized. The differences in the sensitivity and NPV between CECT and PET / CECT in detecting distant metastasis were statistically significant (P <0.05 for each). CONCLUSION: Cross-modality image fusion of PET / CT and CECT is a convenient and effective method that can be used to diagnose and stage PC, compensating for the defects of PET / CT and CECT when they are reflective individually.