钒取代的杂多酸催化一锅四组分Dakin-West反应合成β-乙酰氨基酮(英文)

• 作 者: Reza TAYEBEE Shima TIZABI
• 机 构: Department of Chemistry, School of Sciences, Hakim Sabzevari University,
• 出 处: 催化学报
• 发表日期: 2012年06期
• 关键词: acetonitrile 四组分 aldehyde Wells acetyl 乙酰氨基 ketone condensation Dawson 杂多酸催化

The multicomponent condensation of an aryl aldehyde,acetyl chloride,acetonitrile,and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial,non-corrosive,and environmentally benign Keggin and Wells-Dawson heteropolyacid catalysts.The best catalyst was H5PW10V2O40.The methodology used simple experimental conditions,and the short reaction times and high yields indicate it is a useful strategy for the large scale synthesis of β-acetamido ketones.

The multicomponent condensation of an aryl aldehyde, acetyl chloride, acetonitrile, and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial, non-corrosive, and environmentally benign Keggin and Wells-Dawson heteropolyacid catalysts. best catalyst was H5PW10V2O40. The methodology used simple experimental conditions, and the short reaction times and high-yield scale it is a useful strategy for the large scale synthesis of beta-acetamido ketones.