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目的分析胱抑素C对老年急性脑梗死患者合并早期肾功能损害的检测价值。方法取2010年4月-2012年4月间内蒙古自治区人民医院神经内科收治的老年急性脑梗死患者150例作为研究对象,根据有无肾功能损害分为有早期肾功能损害的观察组患者65例,无肾功能损害的对照组患者85例,比较两组患者的肾功能指标及血胱抑素C浓度差异。结果观察组Ccr、CysC明显高于对照组(P<0.01),Scr、Urea和对照组比较差异无统计学意义(P>0.05);且肾功能分级越差,Ccr水平越低、Urea、CysC和Hcy水平越高;在肾功能Ⅰ期和Ⅱ期的患者中,CysC的异常检出率明显高于Scr和Urea的异常检出率。结论胱抑素C是早期发现老年脑梗死患者并发肾功能损害的有效指标之一。
Objective To analyze the value of cystatin C in the diagnosis of senile acute cerebral infarction complicated with early renal dysfunction. Methods From April 2010 to April 2012 in Inner Mongolia People’s Hospital, Department of Neurology admitted 150 cases of elderly patients with acute cerebral infarction as the object of study, according to the presence or absence of renal impairment was divided into observation group with early renal damage in 65 patients , 85 cases of control group without renal dysfunction, renal function and serum cystatin C concentrations were compared between the two groups. Results The Ccr and CysC in the observation group were significantly higher than those in the control group (P <0.01). There was no significant difference between the Scr and Urea groups and the control group (P> 0.05). The worse the renal function classification, the lower the Ccr level, And Hcy levels higher; in patients with stage I and II of renal function, the abnormal detection rate of CysC was significantly higher than the abnormal detection rate of Scr and Urea. Conclusion Cystatin C is one of the effective indicators of early detection of renal damage in elderly patients with cerebral infarction.