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目的:分析影响伴有负性事件高血压病降压效果的相关因素。方法:收集伴明确负性事件的高血压病患者48例,根据患者病史、血压等具体情况给予硝苯地平缓释片、酒石酸美托洛尔片、盐酸贝那普利片、氯沙坦钾片等药物常规降压治疗。2个月后观察降压治疗效果,采用Logistic多元逐步回归分析评估影响其降压疗效的因素。结果:Logistic多元逐步回归分析结果显示,吸烟史、糖尿病史、冠心病史、生活事件量表评分、家族史、血压分级、焦虑和抑郁均与降压效果存在显著或非常显著相关性(P<0.05,P<0.01),其中,冠心病史、血压分级与降压治疗有效呈显著或非常显著正相关(P<0.05,P<0.01);而吸烟史、糖尿病史、生活事件量表评分、家族史、焦虑和抑郁与降压治疗有效呈显著或非常显著负相关(P<0.05,P<0.01)。结论:对于伴有负性事件的高血压病患者,存在冠心病、糖尿病,高血压分级3级,高血压病家族史,吸烟史,负性事件评分,焦虑和抑郁状态是影响其降压效果的因素。
OBJECTIVE: To analyze the related factors that affect the antihypertensive effect of hypertension associated with negative events. Methods: Forty-eight patients with hypertension with definite negative events were enrolled. Patients were given nifedipine sustained-release tablets, metoprolol tartrate tablets, benazepril hydrochloride tablets, losartan potassium Drugs such as conventional antihypertensive treatment. Two months later, the effect of antihypertensive treatment was observed. Logistic multivariate stepwise regression analysis was used to evaluate the factors influencing antihypertensive effect. Results: Logistic regression analysis showed that smoking history, history of diabetes, history of coronary heart disease, life event scale, family history, blood pressure classification, anxiety and depression had significant or very significant correlation with antihypertensive effect (P < 0.05, P <0.01). Among them, the history of coronary heart disease, blood pressure classification and antihypertensive effect were significantly or very significantly positively correlated (P <0.05, P <0.01); smoking history, history of diabetes, life event scale score, Family history, anxiety, depression and antihypertensive treatment showed a significant or very significant negative correlation (P <0.05, P <0.01). CONCLUSIONS: There is prevalence of coronary heart disease, diabetes mellitus, grade 3 hypertension, family history of hypertension, smoking history, negative event score, anxiety and depression status in hypertensive patients with negative events the elements of.