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本研究测定了３０例Ⅰ期高血压病患者（ＥＨ）伍用三七总皂甙（ＴＳＰＮＳ）和开搏通（Ｃａｐｔｏｐｒｉｌ）治疗前后的左室舒张功能（Ｅ峰、Ａ峰、Ｅ／Ａ、Ｅ面积分数、Ａ面积分数）、左室心肌重量指数（ＬＶＭＩ）红细胞内Ｃａ及其膜上Ｃａ泵活性；并以单用ＣＧ治疗为交叉自身对照。结果显示：经治疗后，ＴＣＧ组Ｅ峰、Ｅ／Ａ、Ｅ面积分数，红细胞膜Ｃａ泵活性明显增加，Ａ峰、Ａ面积分数、ＬＶＭＩ及红细胞内Ｃａ浓度明显减少；与Ｃ组比较差异显著。说明ＴＳＰＮＳ改善左室舒张功能的机理可能与提高心肌细胞膜Ｃａ泵活性，纠正心肌细胞内Ｃａ超负荷及减轻左室心肌重量有关。
This study measured left ventricular diastolic function (E peak, A peak, E/A, E) in 30 patients with stage I hypertension (EH) before and after treatment with TPNS and Captopril. Area fraction, A area fraction), left ventricular myocardial weight index (LVMI), erythrocyte Ca, and Ca pump activity on the membrane; and treated with CG alone as cross-control. The results showed that after treatment, T-peak E-peak, E/A, E area fraction, Ca-pump activity of erythrocyte membrane increased significantly, A-peak, A-area fraction, LVMI, and erythrocyte Ca concentration decreased significantly; compared with C group, the difference was significant. . It is suggested that the mechanism of TSPs improving left ventricular diastolic function may be related to the improvement of myocardial cell membrane Ca pump activity, correction of myocardial intracellular Ca overload and reduction of left ventricular myocardial weight.