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本文报告了继1984年贵州省六盘水市卫生防疫站报道的铝氟联合中毒之后所进行的大白鼠铝氟联合中毒模型的复制。实验用Wistar雄性大鼠88只共分五组,Ⅰ组为对照组,Ⅲ组为高岭土拌煤烘烤玉米组(玉米占饲料的40％);Ⅲ组与Ⅱ组同,但玉米占饲料的80％,Ⅳ组为加AlF_3饮水,Ⅴ组为加NaF饮水。 结果表明,除Ⅰ组外,其余各组均出现氟斑牙,其严重程度与含氟剂量成正比,骨骼X光照片及病理组织学检查均表现出Ⅴ组为骨硬化,Ⅱ、Ⅲ、Ⅳ组出现骨软化,但在实验末期骨软化有逆转现象出现,且这种变化与体内所测各元素的变化情况相吻合,说明铝氟联合中毒与“单纯”氟中毒明显不同。
This article reports the replication of aluminum-fluoride combined poisoning rats following aluminum-fluoride poisoning reported by Sanitary and Antiepidemic Station in Liupanshui City, Guizhou Province in 1984. Eighty Wistar male rats were randomly divided into five groups. Group I was a control group, group III was a kaolin-bake-bake corn group (corn accounted for 40% of the feed), group III was the same as group II, 80%, Ⅳ group plus AlF_3 drinking water, Ⅴ plus NaF drinking water. The results showed that, in addition to group Ⅰ, the other groups were the occurrence of dental fluorosis, the severity is proportional to the dose of fluorine, skeletal X-ray and pathological examination showed group Ⅴ osteosclerosis, Ⅱ, Ⅲ, Ⅳ Group appeared osteomalacia, but in the end of the experimental osteomalacia reversal phenomenon occurs, and this change and changes in the body of the measured element coincides, indicating aluminum fluoride poisoning and “simple” fluorosis significantly different.