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青藤碱系自防己科植物清风藤(Sinome—nium acutum Rehd.et Wils)提取的生物碱之一,具有镇痛、抗炎等多种药理作用。中医以清风藤茎、藤治疗关节肿痛。据近年临床报道,主要以单味清风藤干品水煎服治疗风湿性及类风湿性关节炎100例,显效28例,有效64例;以青藤碱口服、肌注或局部游子透入亦取得显著疗效。鉴于青藤碱化学结构与吗啡近似,故有必要了解长期连用能否产生耐受性与成瘾性,以为进一步阐明其作用原理、提高疗效、临床安全使用提供实验依据。现将实验结果报道如下。
Sinomenine is one of the alkaloids extracted from Sinome-nium acutum Rehd.et Wils, which has many pharmacological effects such as analgesic and anti-inflammatory. Chinese medicine to breeze cane, vine treatment of joint swelling and pain. According to recent clinical reports, 100 cases of rheumatic and rheumatoid arthritis were treated with ShuangJing Decoction alone, 28 cases were markedly effective and 64 cases were effective. With sinomenine orally, intramuscular injection or local vaginal penetration Obtain a significant effect. In view of sinomenine chemical structure and morphine approximation, it is necessary to understand the long-term use can produce tolerance and addiction, in order to further clarify its role, to improve the efficacy and clinical safety to provide experimental evidence. The experimental results are reported below.