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目的探讨采用不同剂量甘露醇治疗脑出血患者的疗效。方法选择息县第二人民医院2013年6月至2015年6月收治的脑出血患者86例,随机分为两组,每组43例。对照组采取全量甘露醇治疗,观察组采取半量甘露醇治疗,对比两组临床疗效情况。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组在治疗7 d后尿素氮和血肌酐水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后NIHSS评分低于对照组,差异有统计学意义(P<0.05)。观察组治疗后肾功能异常发生率低于对照组,差异有统计学意义(P<0.05)。结论采用小剂量甘露醇对于脑出血患者具有显著疗效,能够有效降低肾功能异常发生率,值得临床推广。
Objective To investigate the efficacy of different doses of mannitol in patients with cerebral hemorrhage. Methods Eighty-six patients with cerebral hemorrhage who were selected from the Second People’s Hospital of Xixian County from June 2013 to June 2015 were randomly divided into two groups (43 in each group). The control group to take the total amount of mannitol treatment, the observation group to take half mannitol treatment, the clinical efficacy of the two groups were compared. Results The effective rate of observation group was higher than that of control group (P <0.05). The level of blood urea nitrogen and serum creatinine in observation group was lower than that of control group on the 7th day after treatment (P <0.05) The score of NIHSS in the observation group was lower than that of the control group, the difference was statistically significant (P <0.05). The incidence of renal dysfunction in the observation group was lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Small doses of mannitol have a significant effect on patients with cerebral hemorrhage, can effectively reduce the incidence of renal dysfunction, it is worth clinical promotion.