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目的:检测膀胱尿路上皮癌(BUC)组织中T细胞免疫球蛋白结构域分子3(Tim-3)的表达并探讨其与BUC临床病理特征和预后的关系。方法:采用免疫组织化学方法检测100例BUC及20例正常膀胱组织中Tim-3蛋白的表达,分析其与肿瘤病理分级、分期等临床病理特征的关系,同时研究Tim-3表达水平与BUC患者预后的关系。结果:Tim-3蛋白在BUC中表达率为95%(95/100),而在正常膀胱组织中仅为15%(3/20),差异有显著统计学意义(P<0.001);同时,高级别组和浸润型组BUC中Tim-3蛋白表达水平均明显高于低级别组和浅表型组,差异均具有显著的统计学意义(P=0.001,P=0.004);生存分析结果显示Tim-3蛋白高表达组BUC患者术后生存率明显低于Tim-3蛋白低表达组,单因素和多因素分析显示Tim-3蛋白表达水平是BUC预后的独立危险因素之一。结论:Tim-3蛋白在BUC中存在着过度表达,且其表达与BUC患者预后密切相关,Tim-3可以作为膀胱癌预后的一个独立预测指标。
Objective: To investigate the expression of T-cell immunoglobulin domain 3 (Tim-3) in bladder urothelial carcinoma (BUC) and its relationship with clinicopathological features and prognosis of BUC. Methods: Immunohistochemistry was used to detect the expression of Tim-3 in 100 cases of BUC and 20 cases of normal bladder tissue. The relationship between the expression of Tim-3 and the clinicopathological features of tumor grade and staging was analyzed. The expression of Tim-3 in BUC Prognosis of the relationship. Results: The expression of Tim-3 protein in BUC was 95% (95/100), while it was only 15% (3/20) in normal bladder tissue. The difference was statistically significant (P <0.001) The expression of Tim-3 protein in BUC of high-grade group and infiltrative group were significantly higher than those of the low-grade group and the superficial group (P = 0.001, P = 0.004). The results of survival analysis The survival rate of patients with high expression of Tim-3 in BUC group was significantly lower than that in low expression of Tim-3 protein group. Univariate and multivariate analysis showed that the expression of Tim-3 protein was one of the independent risk factors for prognosis of BUC. Conclusion: Tim-3 protein is overexpressed in BUC and its expression is closely related to the prognosis of patients with BUC. Tim-3 can be used as an independent predictor of bladder cancer prognosis.