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目的:对熊去氧胆酸治疗妊娠期肝内胆汁淤积症(ICP)患者的效果进行评价分析。方法:选择本院104例ICP患者的临床资料,应用平均数字法将其分成A组与B组,各52例,给予B组常规疗法,给予A组患者应用熊去氧胆酸治疗。结果:A组血生化指标、瘙痒症状评分以及妊娠结局等指标均优于B组(P<0.05)。结论:应用熊去氧胆酸治疗ICP患者,可明显改善患者瘙痒症状,并改善患者肝功能、肝酶以及胆汁酸等水平,保障母婴安全,可在临床中预以借鉴。
Objective: To evaluate the effect of ursodeoxycholic acid on patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The clinical data of 104 patients with ICP in our hospital were selected and divided into group A and group B according to the average number method. The patients in group B received routine therapy and the patients in group A were treated with ursodeoxycholic acid. Results: The indexes of blood biochemical index, pruritus symptom score and pregnancy outcome in group A were better than those in group B (P <0.05). Conclusion: The application of ursodeoxycholic acid in the treatment of ICP patients can significantly improve pruritus in patients with symptoms and improve liver function, liver enzymes and bile acids in patients with the level of protection of mother and child safety, which can be used in the clinical reference.