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目的探讨监测血清胱抑素C(CysC)和β2-微球蛋白在糖尿病早期肾病的临床意义。方法采集糖尿病肾病(DN)患者50例,糖尿病未发肾病(DM)患者50例和正常对照组健康人员50例血清,用免疫比浊法检测血清CysC,和β2-微球蛋白,同时用酶法检测Cr的浓度,对所测结果进行统计分析。结果糖尿病肾病(DN)组和糖尿病未发肾病(DM)组血清CysC和β2-微球蛋白水平明显高于对照组,P<0.01。糖尿病未发肾病(DM)组在血肌酐阴性的条件下血清CysC和β2-微球蛋白阳性率分别为44%和36%,明显高于肌酐阳性率。结论血清CysC和β2-微球蛋白在肾损伤早期比肌酐升高更明显,是评价早期肾病的敏感特异性指标,对于临床上发现糖尿病早期肾损害具有指导意义。
Objective To investigate the clinical significance of serum cystatin C (CysC) and β2-microglobulin in early diabetic nephropathy. Methods 50 cases of diabetic nephropathy (DN), 50 cases of diabetic nephropathy (DM) and 50 cases of normal control were enrolled in this study. Serum CysC and β2-microglobulin were detected by immunoturbidimetry, France to measure the concentration of Cr, the measured results were statistically analyzed. Results Serum levels of CysC and β2-microglobulin in diabetic nephropathy (DN) group and diabetic nephropathy (DM) group were significantly higher than those in control group (P <0.01). The positive rates of serum CysC and β2-microglobulin in diabetic nephropathy (DM) group with serum creatinine negative were 44% and 36%, respectively, which were significantly higher than those of creatinine. Conclusions Serum CysC and β2-microglobulin are more obvious than creatinine in the early stage of renal injury, which is a sensitive and specific index to evaluate early nephropathy. It is instructive for the early detection of diabetic nephropathy.